Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors. NEW
Yukari Suda, Keiko Nakamura, Fukiko Matsuyama, Yusuke Hamada, Hitoshi Makabe, Michiko Narita, Yasuyuki Nagumo, Tomohisa Mori, Naoko Kuzumaki & Minoru Narita
DOI: 10.1186/s13041-024-01091-9

Identification of hypoxia-induced metabolism-associated genes in canine tumours NEW
Taiki Kato, Masashi Sakurai, Kenji Watanabe, Yoichi Mizukami, Takayuki Nakagawa, Kenji Baba, Takuya Mizuno, Masaya Igase
DOI: 10.1111/vco.12979

Choledochoduodenostomy combined with Billroth II procedure for extrahepatic biliary obstruction and duodenal perforation in a cat
Shintaro Tomura, Taisuke Iwata, Taichi Sugimoto, Ko Nakashima, Kazuhiro Kojima, Kazuyuki Uchida, and Atsushi Fujita

Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma.
Hiroto Toyoda, Akiyoshi Tani, Yuko Goto-Koshino, Tomoki Motegi, Mika Sakamoto, Takako Mochizuki, Kei Harada, Tetsuya Kobayashi, Asuka Setoguchi, Yohei Shizuta, Takuya Mizuno, Mitsuhiro Irie, Jun Nakamichi, Hajime Tsujimoto, Aki Ohmi, Ray Fukuoka, Yasukazu Nakamura, Hirotaka Tomiyasu
J Vet Med Sci. 2023 Nov 13.　PMID: 37952972　DOI: 10.1292/jvms.23-0269

Clinical features and prognosis of retroperitoneal hemangiosarcoma in dogs with surgical resection with or without adjuvant doxorubicin.
Masanao ICHIMATA, Atsushi TOSHIMA, Fukiko MATSUYAMA,Eri FUKAZAWA, Kei HARADA, Ryuzo KATAYAMA, Yumiko KAGAWA, Tetsushi YAMAGAMI, Tetsuya KOBAYASHI

Intraepithelial lymphocytes are associated with epithelial injury in feline intestinal T-cell lymphoma.
Tatsuhito Ii, James K Chambers, Ko Nakashima, Yuko Goto-Koshino, Kazuyuki Uchida
The Journal of Veterinary Medical Science 2023

Application of automated machine learning for histological evaluation of feline endoscopic samples.
Tatsuhito Ii, James K Chambers, Ko Nakashima, Yuko Goto-Koshino, Kazuyuki Uchida
The Journal of Veterinary Medical Science 2023

Clinicopathological findings, treatment, and outcome in 60 cats with gastrointestinal eosinophilic sclerosing fibroplasia.
Petra Černá, Cristobal Lopez-Jimenez, Kenjiro Fukushima, Ko Nakashima, Taisuke Nakagawa, Fiona Adam, Anna Groth, Andrew Denning, Nicolas Israeliantz, Danièlle A Gunn-Moore
J Vet Intern Med. 2024 Jan 11. doi: 10.1111/jvim.16992.

Pro-inflammatory cytokine expression and the STAT1/3 pathway in canine chronic enteropathy and intestinal T-cell lymphoma.
Kazuhiro Kojima, James K Chambers, Ko Nakashima, Kazuyuki Uchida
Vet Pathol.2023 Oct 31:3009858231207017.　DOI: 10.1177/03009858231207017.

Safety and pharmacokinetics of thalidomide in tumor-bearing dogs
Fukiko Matsuyama , Yukiyoshi Fujita , Eri Fukazawa , Tetsuya Kobayashi
J Vet Med Sci. 2023　PMID: 37813647　DOI: 10.1292/jvms.23-0200

Establishment and characterization of a novel cell line and xenotransplant mouse model derived from feline colorectal adenocarcinoma.
Mizuho Uneyama , James K Chambers , Tadashi Fujii , Ko Nakashima , Kazuyuki Uchida
Vet Pathol. 2023 Jul 29;3009858231189858. doi: 10.1177/03009858231189858.Online ahead of print.

Prognostic value of increased intraepithelial lymphocytes and lymphocytic clonality in dogs with chronic enteropathy or small-cell lymphoma.
K. Nakashima, I. Matsumoto, Y. Goto-Koshino, S. Hiyoshi-Kanemoto, K. Kojima, JK. Chambers, Y. Takeuchi, H. Tsujimoto, H. Tomiyasu, K. Uchida
The Veterinary Journal

Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma.
Hajime Asada, Akiyoshi Tan, Hiroki Sakuma Miyuki Hirabayashi, Yuki Matsumoto , Kei Watanabe, Masaya Tsuboi, Shino Yoshida, Kei Harada, Takao Uchikai, Yuko Goto-Koshino, James K Chambers, Genki Ishihara, Tetsuya Kobayashi, Mitsuhiro Irie, Kazuyuki Uchida, Koichi Ohno, Makoto Bonkobara, Hajime Tsujimoto, Hirotaka Tomiyasu
Sci Rep. 2023 May 25;13(1):8512.

Retrospective study of feline tracheal mass lesions.
Hideyuki Kanemoto Aki Fujiwara-Igarashi, Tetsuya Kobayashi, Kei Harada, Masanao Ichimata, Sangho Kim, Kenji Hosoya, Hirotaka Tomiyasu, Aki Ohmi, Hajime Tsujimoto
J Feline Med Surg. 2023

Prognosis of primary pulmonary adenocarcinoma after surgical resection in small-breed dogs: 52 cases (2005-2021).
Masanao Ichimata, Yumiko Kagawa, Keita Namiki, Atsushi Toshima, Yuko Nakano, Fukiko Matsuyama, Eri Fukazawa, Kei Harada, Ryuzo Katayama, Tetsuya Kobayashi
J Vet Intern Med. 2023

Intraepithelial cytotoxic lymphocytes are associated with a poor prognosis in feline intestinal T-cell lymphoma
Tatshuhito Ii , James K. Chambers, Ko Nakashima, Yuko Goto-Koshino, Takuya Mizuno and Kazuyuki Uchida

Evaluation of adverse events in small-breed dogs treated with maropitant and a single dose of doxorubicin
Fukiko Matsuyama, Kei Harada, Eri Fukazawa, Masanao Ichimata, Yuko Nakano, Tetsuya Kobayashi
Journal of Veterinary Internal Medicine. 07 May 2022

Radiographic characteristics of canine subungual keratoacanthoma
Atsushi Toshima, Caroline V. Fulkerson, Garret S. Oetelaar, Yumiko Kagawa, Hajime Aoki, Masami Higuchi, Kotomi Sawa, Yozo Kawamura, Kaji Seino, Atsushi Sugiyama, Shogo Otaki, Masahiro Murakami
Wiley Online Library. 29 March 2022

Intrapancreatic accessory spleen mimicking pancreatic insulinoma with intrapancreatic metastasis in a cat
Shintaro Tomura, Atsushi Toshima, Akira Nomura, Masahiko Hirata, Tetsushi Yamagami, Yumiko Kagawa, Tsuyoshi Kadosawa
J Vet Med Sci. 2022 Feb 2

Ultrasonographic patterns, clinical findings, and prognostic variables in dogs from Asia with gallbladder mucocele
Jared A. Jaffey, Rachael Kreisler, Kate Shumway, Yan-Jane Lee, Chung-Hui Lin, Lawren L. Durocher-Babek, Kyoung-Won Seo, Hojung Choi, Ko Nakashima, Hiromi Harada, Hideyuki Kanemoto, Lee-Shuan Lin
J Vet Intern Med. 2022 Feb 15

Phenotypic and Genetic Characterization for Incompatible Cross-Match Cases in the Feline AB Blood Group System
Yumiko Uno, Masami Yaguchi, Tasuku Kobayashi, Eri Onozawa, Kazuhiko Ochiai, Karin Yoshida, Chihiro Nakamura, Chihiro Udagawa and Toshinori Omi
Front. Vet. Sci., 13 September 2021

Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples.
K Kojima, JK. Chambers, K Nakashima, Y Goto-Koshino、K Uchida
Vet Pathol. 2021 November 18

Long-term survival in a dog with primary hepatic neuroendocrine tumor treated with toceranib phosphate
Masanao Ichimata, Shinichiro Nishiyama, Fukiko Matsuyama, Eri Fukazawa, Kei Harada, Ryuzo Katayama, Atsushi Toshima, Yumiko Kagawa, Tetsushi Yamagami, Tetsuya Kobayashi
J Vet Med Sci. 2021 Aug 17.doi: 10.1292

Feline pyloric and duodenal adenoma: A histological and immunohistochemical study
M Uneyama, JK Chambers, K Nakashima, K Uchida
Vet Pathol July 16, 2021

Construction and validation of a scoring system to predict resistance to chemotherapeutic drugs using gene expression profiles in canine lymphoma
A. Tani, Y. Saegusa, K. Ogawa a, H. Tomiyasu, Y. Takeuchi, K. Harada, T. Kobayashi, A. Setoguchi, J. Nakamichi, T. Mizuno, M. Irie, M. Tokita, K. Fujita, M. Suenaga, T. Motegi, A. Ohmi, Y. Goto-Koshino, K. Ohno, H. Tsujimoto
Research in Veterinary Science 137 (2021) 208‐216

Immunophenotyping of Nonneoplastic and Neoplastic Histiocytes in Cats and Characterization of a Novel Cell Line Derived From Feline Progressive Histiocytosis.
Hirabayashi M, Chambers JK, Sumi A, Harada K, Haritani M, Omachi T, Kobayashi T, Nakayama H, Uchida K.
Vet Pathol. 2020 Nov;57(6):758-773. doi: 10.1177/0300985820953538. Epub 2020 Sep 4.PMID: 32885737

Histological Classification and Immunohistochemical Study of Feline Colorectal Epithelial Tumors
Mizuho Uneyama, James K Chambers, Ko Nakashima, Kazuyuki Uchida, Hiroyuki Nakayama
Vet Pathol. 2020 Nov 19;300985820974279. doi: 10.1177/0300985820974279.

Immunohistochemical analysis of beta-catenin, E-cadherin and p53 in canine gastrointestinal epithelial tumors.
Tsubasa SAITO, James K. CHAMBERS, Ko NAKASHIMA, Kazumi NIBE, Koichi OHNO, Hajime TSUJIMOTO, Kazuyuki UCHIDA, Hiroyuki NAKAYAMA
Journal of Veterinary Medical Science [Advance publication] Released: July 13, 2020

A histopathological study on spontaneous gastrointestinal epithelial tumors in dogs
Tsubasa SAITO, Kazumi NIBE, James K. CHAMBERS, Mizuho UNEYAMA, Ko NAKASHIMA, Koichi OHNO, Hajime TSUJIMOTO, Kazuyuki UCHIDA, Hiroyuki NAKAYAMA
Journal of Toxicologic Pathology J-STAGEAdvancePublishedDate: January25,2020

Escherichia coli-induced granulomatous colitis in a cat.
Matsumoto I, Nakashima K, Morita H, Kasahara K, Kataoka O, Uchida K.
Journal of Feline Medicine and Surgery Open Reports. 2019 Mar 14;5(1)

Immunohistochemical Profiling of Canine Intestinal T-Cell Lymphomas
Isao Matsumoto, Ko Nakashima, Yuko Goto-Koshino, James Kenn Chambers, Hajime Tsujimoto, Hiroyuki Nakayama, Kazuyuki Uchida
Veterinary Pathology 2018

Histopathologic Features of Colorectal Adenoma and Adenocarcinoma Developing Within Inflammatory Polyps in Miniature Dachshunds.
Saito T, Chambers JK, Nakashima K, Uchida E, Ohno K, Tsujimoto H, Uchida K, Nakayama H.
Vet Pathol. 2018 Jan 1:300985818777798. doi: 10.1177/0300985818777798. [Epub ahead of print]

Pathological features of intestinal T‐cell lymphoma in Shiba dogs in Japan
I. Matsumoto, K. Uchida, K. Nakashima, Y. Goto‐Koshino, J. K. Chambers, H. Tsujimoto, H. Nakayama.
Vet Comp Oncol. 2018 March 25

IgA Antibodies Against Gliadin and Tissue Transglutaminase in Dogs With Chronic Enteritis and Intestinal T-Cell Lymphoma.
I. Matsumoto, K. Uchida, K. Nakashima, S. Hiyoshi, J. K. Chambers, H. Tsujimoto, H. Nakayama
Vet Pathol. 2017 February 21

Epidemiological study on feline gastric Helicobacter spp. in Japan.
Kubota-Aizawa S, Ohno K, Kanemoto H, Nakashima K, Fukushima K, Uchida K, Chambers JK, Goto-Koshino Y, Mimuro H, Watanabe T, Sekizaki T, Tsujimoto H.
J Vet Med Sci. 2017 May 18;79(5):876-880.

Identification of a secondary mutation in the KIT kinase domain correlated with imatinib-resistance in a canine mast cell tumor.
Nakano Y, Kobayashi M, Bonkobara M, Takanosu M.
Vet Immunol Immunopathol. 2017 June;188:84-88.

Validity and reliability of the Patient Centred Assessment Method for patient complexity and relationship with hospital length of stay: a prospective cohort study.
Yoshida S, Matsushima M, Wakabayashi H, Mutai R, Murayama S, Hayashi T, Ichikawa H, Nakano Y, Watanabe T, Fujinuma Y.
BMJ Open. 2017 May 9;7(5):e016175.

Psychological impact of lifestyle-related disease disclosure at general checkup: a prospective cohort study.
Tominaga T, Matsushima M, Nagata T, Moriya A, Watanabe T, Nakano Y, Hirayama Y, Fujinuma Y.
BMC Fam Pract. 2015 May 14

Cloning and expression analysis of prohibitin mRNA in canine mammary tumors.
Matsuyama S, Nakano Y, Nakamura M, Yamamoto R, Shimada T, Ohashi F, Kubo K.
J Vet Med Sci. 2015 Jan;77(1):101-4.

Pathologic Features of Colorectal Inflammatory Polyps in Miniature Dachshunds
E. Uchida, J. K. Chambers, K. Nakashima, T. Saito, K. Ohno, H. Tsujimoto, H. Nakayama, and K. Uchida
Vet Pathol. 2016 January 20. [Epub ahead of print]

Localized pulmonary histiocytic sarcomas in Pembroke Welsh Corgi.
Kagawa Y, Nakano Y, Kobayashi T, Asano K, Takagi S.
J Vet Med Sci. 2015 Jul 4.

Computed tomographic features of canine nonparenchymal hemangiosarcoma.
Fukuda S, Kobayashi T, Robertson ID, Oshima F, Fukazawa E, Nakano Y, Ono S, Thrall DE.
Vet Radiol Ultrasound. 2014 Jul-Aug;55(4):374-9.

Mycotic aneurysm caused by Graphium species in a dog.
Murata Y, Chambers JK, Uchida K, Nakashima K, Hanafusa Y, Ikezawa M, Sugita T, Nakayama H.
J Vet Med Sci. 2015 May 3. [Epub ahead of print]

Association between lymphocyte antigen receptor gene rearrangements and histopathological evaluation in canine chronic enteropathy.
Hiyoshi S, Ohno K, Uchida K, Goto-Koshino Y, Nakashima K, Fukushima K, Kanemoto H, Maeda S, Tsujimoto H.
Vet Immunol Immunopathol. 2015 Jun 15;165(3-4):138-44.

Imatinib Responsiveness in Canine Mast Cell Tumors Carrying Novel Mutations of c-KIT Exon 11.
Nakano Y, Kobayashi T, Oshima F, Fukazawa E, Yamagami T, Shiraishi Y, Takanosu M.
J Vet Med Sci. 2013 Nov 29. [Epub ahead of print]

Efficacy of hypofractionated radiotherapy for nasal tumours in 38 dogs (2005-2008).
Fujiwara A, Kobayashi T, Kazato Y, Yayoshi N, Fujita M.
J Small Anim Pract. 2013 Feb;54(2):80-6

Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases.
Junko CHINO, Yasuhito FUJINO, Tetsuya KOBAYASHI, Kazuhiro KARIYA, Yuko GOTO-KOSHINO, Koichi OHNO, Hiroyuki NAKAYAMA and Hajime TSUJIMOTO
J. Vet. Med. Sci. 75(6): 701-707, 2013.

Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours: A retrospective cohort study.
Yoshinori Takeuchi, Yasuhito Fujino, Manabu Watanabe, Masashi Takahashi, Takayuki Nakagawa, Ayano Takeuchi, Makoto Bonkobara, Tetsuya Kobayashi, Koichi Ohno, Kazuyuki Uchida, Kazushi Asano, Ryohei Nishimura, Hiroyuki Nakayama, Sumio Sugano, Yasuo Ohashi and Hajime Tsujimoto.
The Veterinary Journal; 196: 492-498 (2013).

Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma.
Sato M, Kanemoto H, Kagawa Y, Kobayashi T, Goto-Koshino Y, Mochizuki H, Takahashi M, Fujino Y, Ohno K, Tsujimoto H.
Vet J. 2011 Jan 28.

Heteroduplex polymerase chain reaction is essential for canine receptorrearrangement analysis.
Takanosu M, Tadika T, Kobayashi T.
J Vet Diagn Invest. 2010 Sep;22(5):760-3.

Effect of Tyrosine Kinase Inhibition by Imatinib Mesylate on Mast Cell Tumors in Dogs
M. Isotani, N. Ishida, M. Tominaga, K. Tamura, H. Yagihara, S. Ochi, R.
Kato, T. Kobayashi, M. Fujita, Y. Fujino, A.Setoguchi, K. Ono, T. Washizu, and M. Bonkobara
J Vet Intern Med 22(4):985-988, 2008.